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DRAXIMAGE® DTPA is a kit for the preparation of Technetium Tc 99m pentetate injection. Technetium Tc 99m pentetate is a radioactive diagnostic agent indicated for: Brain imaging in adults with intravenous injection; Renal visualization, assessment of renal perfusion, and estimation of glomerular filtration rate in adult and pediatric patients with intravenous injection; Lung ventilation imaging and evaluation of pulmonary embolism when paired with perfusion imaging in adult and pediatric patients when administered by nebulizer for inhalation.
Diethylenetriamine pentacetic acid (DTPA) is used to assess pulmonary ventilation function in association with macroaggregated albumin (MAA) to perform a ventilation/perfusion (V/Q) scan. Once deposited in the lungs, the 99mTc-DTPA aerosol particles remain in place for sufficient time to allow nuclear technologists to image multiple projections of the lungs in either SPECT or planar modes..
The blood-brain barrier (BBB) refers to the anatomic and physiologic membrane between circulating blood and the brain preventing certain damaging substances from reaching brain tissue and cerebrospinal fluid. This barrier permits nutrients essential to brain tissue to readily cross the barrier while toxic and unwanted substances are restricted from passage. DRAXIMAGE® DTPA is a non-lipophilic agent that cannot penetrate the blood-brain barrier, unless there is a breakdown in the BBB as a result of disease.
Complemented by other imaging modalities, radionuclide imaging has emerged as an important diagnostic tool in nephrology, urology, and renal transplantation. This functional information can be correlated to anatomical information from these complementary imaging studies or simultaneous hybrid imaging (eg, SPECT/CT).
Renal imaging and functional studies are recognized, well accepted, and proven as reliable means to evaluate the structure, function and physiology of the urinary tract as well as to determine the total and differential performance of the kidneys. This can be accomplished without danger of allergic reactions that are more common with iodinated X-ray contrast agents, unpleasant side effects, or excessive radiation dose to the organs involved.
Kit for the Preparation of Technetium Tc 99m Pentetate Injection
Each kit consists of reaction vials which contain the sterile, non-pyrogenic, non-radioactive ingredients necessary to produce Technetium Tc 99m Pentetate Injection for diagnostic use by intravenous injection or for inhalation after the nebulization to radio-aerosol. Available in kits containing 10 reaction vials.
Hypersensitivity to any component of this product
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This information is not intended as medical advice. Responsibility for patient care resides with the healthcare professional on the basis of his or her professional license, experience and knowledge of the patient. For full Prescribing Information including indications, contraindications, warnings, precautions and adverse events, please see the appropriate product labeling.