The RUBY-FILL® Rubidium 82 Generator contains an accelerator produced Strontium-82, which decays to Rubidium-82. When the generator is eluted with saline it produces a sterile, non-pyrogenic solution of Rb-82 Chloride.

Due to the short half-life (75 s) of Rb-82, the use of an elution system is required for delivery of the Rb-82 Chloride into a patient for the purposes of performing Myocardial Perfusion Imaging with PET.  PET imaging with Rb-82 Chloride may be performed under rest and/or stress conditions.

The Rubidium Elution System has been exclusively designed to be used with the RUBY-FILL® generator and to deliver accurate doses of Rb-82 Chloride to patients.

Important Safety Information
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RUBY-FILL™ (Rubidium Rb 82 Generator) produces a parenteral solution of 82RbCl (Rubidium Chloride Rb 82 Injection) for intravenous infusion. Rubidium Chloride Rb 82 Injection is indicated as an accessory to positron emission tomography (PET) for imaging of the myocardium, to evaluate regional myocardial perfusion in adult patients, as an aid in the diagnosis or assessment of suspected or known coronary artery disease


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  • Unintended radiation exposure occurs when the levels of Sr 82 or Sr 85 in the rubidium Rb 82 chloride injection exceed specific limits.
  • Perform generator eluate tests:

1) Determine Rb 82, Sr 82, Sr 85 levels in the eluate:

  •  Once daily, prior to any drug administration, and
  •  With additional daily tests after detection of an Alert Limit.

2) Stop use of the generator at its Expiration Limit.

Safety Data Sheets

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Fiche de données de sécurité